Biotechnology (BIOT)

BIOT 5040. Fundamentals of Biochemistry for Biotechnology. 4 Hours.

Covers the fundamentals of biochemistry for biotechnology applications, including protein structure and function, DNA technologies, bioenergetics, and biosynthesis. Prereq. Restricted to biotechnology students or by permission of instructor.

BIOT 5050. Organic Chemistry for Biotechnology. 4 Hours.

Offers an introduction to organic chemistry that seeks to prepare students for the MS in biotechnology program. Explores the nature of and the biological aspects of organic compounds. Covers the fundamentals of the structure, nomenclature, properties, and reactions of carbon compounds. Also introduces the chemistry of biological molecules, including amino acids, proteins, carbohydrates, and lipids, as well as spectroscopic structure determination known as nuclear magnetic resonance (NMR). Prereq. Chemical principles 2/general chemistry 2 with lab; restricted to biotechnology students or by permission of instructor.

BIOT 5120. Introduction to Biotechnology. 3 Hours.

Provides an interdisciplinary, state-of-the-art introduction to biotechnology to students of the Master of Science in Biotechnology program. Covers the molecular foundations of biotechnology, molecular microbiology, receptor pharmacology, drug development processes, biotech process development and scale-up, drug approval and regulatory affairs, genomics, microarray analysis, proteomics, computational biology, molecular modeling, analytical biotechnology, and bioterrorism and biotechnology. Prereq. Junior, senior, or graduate standing.

BIOT 5130. Team Skills in Biotechnology. 2 Hours.

Focuses on project management and leadership skills in the biotechnology industry. Emphasizes professional etiquette, teamwork, and team leadership in a diverse, multidisciplinary workplace. Also offers students an opportunity to develop their technical communication skills (scientific writing, public speaking, and technical presentations). Prereq. Junior, senior, or graduate standing.

BIOT 5145. Basic Biotechnology Lab Skills. 1 Hour.

Introduces selected key skills and techniques central to life sciences research. Combines hands-on training in basic laboratory skills with lecture and live demonstration. Laboratory exercises highlight the importance of precision/accuracy in dispensation of liquids and in the preparation of solutions and standards, documentation and record keeping, and maintaining a safe and sterile work environment while performing scientific research. Prereq. Junior, senior, or graduate standing; biotechnology students only.

BIOT 5219. The Biotechnology Enterprise. 2 Hours.

Exposes students to a broad spectrum of concepts and issues that are common to biotechnology companies. Provides an overview of innovation, intellectual property, planning, government regulation, and strategic alliances. Introduces biotechnology entrepreneurship; management; and the legal aspects of science, technology, and research in the biotechnology context. Prereq. Junior, senior, or graduate standing; restricted to students in biotechnology, bioinformatics, and regulatory science of biopharmacy.

BIOT 5220. The Role of Patents in the Biotechnology Industry, Past and Future. 1 Hour.

Covers the basics of patenting and the application of patents to the biotechnology industry, including the controversial area of gene patents.

BIOT 5225. Managing and Leading a Biotechnology Company. 3 Hours.

Covers managing projects and personnel in a technology-based organization Such activities are best carried out by those who combine the technical knowledge of their industry with the insight into the best practices for working with groups of highly educated, and often very experienced people. The biotechnology industry is strongly dependent on the concept that knowledge is always shared and ownership is collective. As the fundamental organizational mantra is teamwork, the principles of managing in this environment are key to achieving important goals. How to accomplish this and make decisions that drive innovation and success have common threads with other technology based industries, but with the added complexity of the scientific challenges facing the biotechnology industry. Restricted to students in the Bouvé College of Health Sciences and in the College of Science or by permission of the program office.

BIOT 5226. Biotechnology Entrepreneurship. 3 Hours.

Biotechnology by its very nature is an innovative multidisciplinary industry. This is especially true for the biopharmaceutical industry in which the process of discovering new drugs and new drug targets requires novel approaches to solving difficult questions about disease processes and human health. This course focuses on the essential nature of innovation in the biotech industry, exposes students to the basics of creating startup organizations, explains the key role of business planning in enterprise creation, describes means for assessing risks, making choices from available options and how to measure success. Various business models, outsourcing work and establishing strategic partnerships are examined. Restricted to students in the Bouvé College of Health Sciences and in the College of Science or by permission of the program office.

BIOT 5227. Economics and Marketing for Biotechnology Managers. 3 Hours.

Provides a foundation for making financial decisions in the biotechnology industry. Examines accounting methods, forecasting, corporate valuation, exit strategies and drug pipeline economics. Introduces concepts for marketing pharmaceutical products. Restricted to students in the Bouvé College of Health Sciences and in the College of Science or by permission of the program office.

BIOT 5330. Drug Safety and Immunogenicity. 3 Hours.

Introduces the fundamental molecular interactions involved in immunological responses as well as in measuring and testing in a research and regulated environment. Other drug-safety-related topics include adventitious agents (viruses, microorganisms, mycoplasma) and risk factors such as product-related substances (aggregates and post-translationally modified variants), endotoxins, DNA, host-cell proteins, process contaminants such as antibiotics, and the means of testing and removing these through validated processes.

BIOT 5560. Bioprocess Fundamentals. 3 Hours.

Focuses on the fundamental principles and elements in the process of manufacturing biopharmaceuticals. Covers kinetics of enzymatic reactions; selected microbial and cell metabolism and relevant control mechanisms; kinetics of cell growth, cell death, substrate consumption, and product formation; mathematical modeling and representation of bioprocesses; examples of industrial bioprocesses to illustrate types and operations of upstream and downstream unit operations and mass transfers in fermentation systems—the affecting factors and the impact on process development and scale-up. Also includes an overview of economic considerations. Emphasizes bioprocesses for recombinant protein production.

BIOT 5631. Cell Culture Processes for Biopharmaceutical Production. 3 Hours.

Covers the principles and concepts involved in the development of mammalian and other types of cell culture processes for the manufacturing of biopharmaceutical products such as monoclonal antibodies and recombinant proteins. Topics include protein expression and clone generation, batch and perfusion processes and media development, bioreactor operations and scale-up, and innovations in cell culture processes. Regulatory concepts include quality assurance in a cGMP environment.

BIOT 5635. Downstream Processes for Biopharmaceutical Production. 3 Hours.

Addresses the development of recombinant protein purification processes in biotechnology. Provides an overview of the scientific principles, engineering strategies, and unit operations facilities involved in scalable protein purification processes. Also discusses viral clearance and inactivation strategies; cGMP considerations; and technological advances to improve effectiveness and efficiency, such as membrane-based disposable systems.

BIOT 5640. Drug Product Processes for Biopharmaceuticals. 3 Hours.

Covers the development and implementation of the drug product manufacturing process for biopharmaceuticals. Focuses on biologic products, specifically proteins. Covers the workflow required for the development and implementation of the production process with the scientific and engineering principles highlighted. Topics include the preformulation process for early stage product development, the selection of formulation compatible with the targeted product presentation, optimization of formulations to meet stability and usage objectives, the design of a scalable process for production, large-scale process equipment and operations, process scale-up considerations, and regulatory compliance issues for drug product manufacturing facilities and operations. Prereq. CHEM 5620 or permission of instructor.

BIOT 5700. Molecular Interactions of Proteins in Biopharmaceutical Formulations. 3 Hours.

Offers an up-to-date survey and review of the research and understanding of the molecular interactions of proteins in biopharmaceutical formulations, including both liquid and solid formats, during the process of drug product manufacturing. Focuses on protein-protein interactions, protein-excipients (e.g., stabilizers, surfactants) interactions, and protein at interface surfaces interactions that are critical and impactful on the stability and integrity of therapeutic proteins of interest. Emphasizes understanding the mechanistic aspect of the interactions; the approaches, methods, and techniques employed to study these phenomena; and measures considered to modulate such interactions to enhance the performance of the biopharmaceutical formulations. Prereq. CHEM 5620 or permission of instructor.

BIOT 6214. Experimental Design and Biometrics. 2 Hours.

Explores the principles of experimental design and statistical analysis. Emphasizes research in the molecular and biological sciences and biotechnology. Topics include probability theory, sampling hypothesis formulation and testing, and parametric and nonparametric statistical methods.

BIOT 6400. Pre-co-op Experience. 0 Hours.

Offers students an opportunity to gain necessary skills and practical experience in order to prepare for graduate co-op. Prereq. Restricted to students in biotechnology and in regulatory science of biopharmacy.

BIOT 6411. Biotechnology Co-op Reflection Seminar. 1 Hour.

Designed to complement learning during or after graduate co-op placement. Students participate in activities to integrate academic learning and experiential learning, including written reflections and weekly reports that do not have to include company confidential information. Prereq. Restricted to students in biotechnology and in regulatory science of biopharmacy.

BIOT 6500. Professional Development for Co-op. 0 Hours.

Introduces the cooperative education program. Offers students an opportunity to develop job-search and career-management skills; to assess their workplace skills, interests, and values and to discuss how they impact personal career choices; to prepare a professional resumé; and to learn proper interviewing techniques. Explores career paths, choices, professional behaviors, work culture, and career decision making. Prereq. Biotechnology and bioinformatics students only.

BIOT 6962. Elective. 1-4 Hours.

Offers elective credit for courses taken at other academic institutions.

BIOT 6964. Co-op Work Experience. 0 Hours.

Provides eligible students with an opportunity for work experience. Prereq. Restricted to students in biotechnology and in regulatory science of biopharmacy.

BIOT 7245. Biotechnology Applications Laboratory. 3 Hours.

Presents a laboratory course in biotechnology with a focus on cutting-edge instrumentation that is currently used in the field. Directs special attention at the practical aspects of laboratory work in this field, for example, techniques in sample preparation, procedures for protein analysis, and new bioinformatic approaches. Focuses on the emerging field of chemiproteomics, which is the study of the interaction of small molecules with the proteome, that is, the full complement of proteins expressed in an individual cell or organism. Exposes the student to hands-on experience with modern instrumentation, such as mass spectrometry and high performance liquid chromatography.

BIOT 7300. Special Topics in Biotechnology. 1-3 Hours.

Presents selected topics of current importance in biotechnology.

BIOT 7303. Special Topics in Biopharmaceutical Regulatory Science. 3 Hours.

Presents selected topics of current importance in biotechnology and biopharmaceutical regulatory science.