Biotechnology - CPS (BTC)

BTC 1300. Introduction to Biotechnology. 3 Hours.

Introduces the integrated science of genomics, proteomics, and bioinformatics using a case study, hands-on, problem-solving approach. Offers students an opportunity to practice accessing and using online databases to engage in real-time discoveries using the same approach current scientists use in their own research. Focuses on the process of doing genomic analysis and thinking from a genomics perspective. Uses integrated multimedia and Web resources to introduce new technologies and to allow students to research and analyze real genomics data.

BTC 1990. Elective. 1-4 Hours.

Offers elective credit for courses taken at other academic institutions.

BTC 2990. Elective. 1-4 Hours.

Offers elective credit for courses taken at other academic institutions.

BTC 3300. Biomaterials. 3 Hours.

Covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between biological and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces.

BTC 3990. Elective. 1-4 Hours.

Offers elective credit for courses taken at other academic institutions.

BTC 4200. Genomics and Proteomics. 3 Hours.

Focuses on bioinformatics and its importance in the sciences. Seeks to apply and understand bioinformatics tools as they pertain to analyses of genomes, protein structure/function, gene families, and molecular evolution. Uses bioinformatics tools to mine databases for information relevant to answering questions relating to molecular structure, function, and evolution. Analyzes relationships between known protein structure and model protein structures. Illustrates how multiple alignments and database searching are used to gather data about gene sequences. Describes how to identify genes and infer gene structure. Differentiates between the types of phylogenetic analyses available and appropriate programs for specific questions. Applies students’ existing content knowledge toward practical bioinformatic applications Offers students an opportunity to develop skills in analysis, problem solving, and communication as applied to bioinformatics.

BTC 4300. Biotechnology and Pharmaceutical Processing. 3 Hours.

Focuses on the fundamental principles and elements in the process of manufacturing biopharmaceuticals using current good manufacturing practices (CGMPs). Covers kinetics of enzymatic reactions; selected microbial and cell metabolism and relevant control mechanisms; kinetics of cell growth, cell death, substrate consumption, and product formation; mathematical modeling and representation of bioprocesses; examples of industrial bioprocesses to illustrate types and operations of upstream and downstream unit operations and mass transfers in fermentation systems. Emphasizes bioprocesses for recombinant protein production. Selected methods, techniques, and instruments used in biotechnology are explored in depth. Provides students with up-to-date good manufacturing practices used in biotech/biopharmaceutical industries and explains how those practices influence quality control/management of downstream products. Prereq. BTC 1300 and BIO 2300.

BTC 4450. Quality Control and Validation Issues. 3 Hours.

Introduces the regulations and guidelines affecting the development, production, registration, and sale of medical devices, diagnostics, pharmaceuticals, and biotechnology products worldwide. Focuses on why regulations are necessary, ethical considerations, and international standards. Offers practical instruction in the basics of quality control and process/facility validation for the biotechnology industry. Reviews appropriate regulations, including personnel and process flow, environmental and water testing, sterility testing, and incoming material and in-process testing. Other topics include the establishment of a master validation plan; description of facility, equipment, and process validations; and cleaning validations.

BTC 4850. Biotechnology Senior Project. 3 Hours.

Focuses on an in-depth project in which a student conducts research or produces a product related to the student’s major field.

BTC 4950. Seminar. 1-4 Hours.

Offers an in-depth study of selected topics. Prereq. Senior standing.

BTC 4955. Project. 1-4 Hours.

Focuses on in-depth project in which a student conducts research or produces a product related to the student’s major field.

BTC 4983. Topics. 1-4 Hours.

Covers special topics in biotechnology.

BTC 4990. Elective. 1-4 Hours.

Offers elective credit for courses taken at other academic institutions.

BTC 4991. Research. 1-4 Hours.

Offers students an opportunity to conduct research under faculty supervision.

BTC 4992. Directed Study. 1-4 Hours.

Offers independent work under the direction of members of the department on a chosen topic. Prereq. Junior or senior standing.

BTC 4993. Independent Study. 1-4 Hours.

Offers independent work under the direction of members of the department on a chosen topic.

BTC 4994. Internship. 1-4 Hours.

Provides students with an opportunity for internship work.

BTC 4995. Practicum. 1-4 Hours.

Provides eligible students with an opportunity for practical experience.

BTC 4996. Experiential Education Directed Study. 1-4 Hours.

Draws upon the student’s approved experiential activity and integrates it with study in the academic major.

BTC 5976. Directed Study. 1-4 Hours.

Offers independent work under the direction of members of the department on a chosen topic.

BTC 5978. Independent Study. 1-4 Hours.

Offers independent work under the direction of members of the department on a chosen topic.

BTC 5984. Research. 1-4 Hours.

Offers students an opportunity to conduct research under faculty supervision.

BTC 6115. Genomics and Bioinformatics: Basic Science and Technology. 4 Hours.

Introduces the history, essential theory, and application of bioinformatics from early Mendelian genetics through genome mapping and sequencing technologies. Offers students an opportunity to learn methods for modeling metabolic and regulatory pathways with a focus on protein structure prediction through a combination of mRNA and protein expression data.

BTC 6125. Expression Analysis. 4 Hours.

Surveys available expression measurement techniques with a discussion of their relative strengths and weaknesses. The explosion in microarray technologies allows scientists to measure the expression level of thousands of genes simultaneously from a single biological sample on one “gene chip.” The course offers students an opportunity for hands-on practice searching databases for sequence similarities. Discusses data visualization and clustering and analysis, including applications to toxicology, drug target, and diagnostic marker discovery.

BTC 6135. Proteomics. 4 Hours.

Explores the basics of how one analyzes proteins and proteomes and how these approaches are used to investigate their roles in living systems. The systematic analysis of protein profiles of healthy and diseased tissues is rapidly transforming the practice of biology by making it possible to understand complex biological systems as collections of proteins. Building on the key concepts of proteomics, explores how the analytical instrumentation works, what data mining and other software tools do, and how these tools can be integrated to study proteomes to open new opportunities in drug discovery and development. .

BTC 6210. Human Experimentation: Methodological Issues Fundamentals. 4 Hours.

Explores issues related to human experimentation, including methodological issues and the ethical, clinical, and financial repercussions of clinical trial studies. Covers how effective study designs can mitigate the common limitations and problems of clinical trials. Considers ethical issues, such as selective reporting of clinical research, informed consent, and protection of research participants in domestic and international clinical trials.

BTC 6211. Validation and Auditing of Clinical Trial Information. 4 Hours.

Presents a comprehensive overview of the management of quality assurance in clinical trials, Good Clinical Practices (GCP), and management of audit outcomes, as well as current issues and trends in the validation and auditing of clinical studies. Prereq. RGA 6210. .

BTC 6213. Clinical Trial Design Optimization and Problem Solving. 4 Hours.

Discusses quantitative data analysis in creating dynamic drug-disease models, strategic market models, trial simulation models, and integrated financial models, which enable key variable analysis in clinical trial developments in real time. This integrated approach allows all decisions in the design to optimize value against both scientific and business criteria simultaneously and continuously. Offers students an opportunity to learn to take a complete view of the development process at the outset—across time, across the portfolio, and at all levels in the organization. This allows for greater insight into a drug’s potential early in the process and leads to a more focused program for promising compounds, including an optimized clinical trial design. It also allows for earlier cessation of unpromising clinical trials, saving time and funds. Prereq. RGA 6100 or RGA 6201. .

BTC 6260. The Business of Medicine and Biotechnology. 4 Hours.

Considers current case studies in order to understand how and why certain medical products succeed while others do not. Understanding how integrating cost, reimbursement, intellectual property, product liability, and FDA issues into an overall product development strategy is vital in bringing a new medical product to the U.S. market. And in light of high-profile product failures such as VIOXX and others, reimportation of drugs, reuse of single-use medical devices, and the impact of generic biologics, keeping your medical product on the market can be as much of a challenge as getting it there. The course concludes with a group debate where students recreate an FDA panel meeting to try and understand the FDA approval process.

BTC 6961. Internship. 1-4 Hours.

Provides students with an opportunity for internship work.

BTC 6962. Elective. 1-4 Hours.

Offers elective credit for courses taken at other academic institutions.

BTC 6964. Co-op. 0 Hours.

Provides eligible students with an opportunity for work experience.

BTC 6966. Practicum. 1-4 Hours.

Provides eligible students with an opportunity for practical experience.

BTC 6970. Seminar. 1-4 Hours.

Offers an in-depth study of selected topics.

BTC 6980. Capstone. 1-4 Hours.

Offers students an opportunity to integrate their course work, knowledge, and experiences into a capstone project.

BTC 6983. Topics. 1-4 Hours.

Covers special topics in biotechnology.

BTC 6995. Project. 1-4 Hours.

Focuses on in-depth project in which a student conducts research or produces a product related to the student’s major field.